In defence mode: this is how Zika virus protects key parts of its genome

(Scuola Internazionale Superiore di Studi Avanzati) To fight viruses, cells can deploy defence enzymes that progressively destroy viral genome. However, this degradation mechanism is not effective against epidemic viruses like Zika. In fact, the defence enzyme jams at precise points of the viral genome, which assumes a " defensive " conformation. This is how the virus succeeds at protecting important pieces of its RNA inside infected cells, as demonstrated by a recent study coordinated by SISSA and published in Nature Communications.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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(University of California - Riverside) A research team led by scientists at the University of California, Riverside, has outlined how the Zika virus, which constituted an epidemic threat in 2016, suppresses the immune system of its host. The work provides valuable structural and functional information on the interaction between ZIKV and its host and offers a framework for the development of vaccines and antivirals.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
As the COVID-19 pandemic continues to progress, the medical community is rapidly trying to identify complications and patterns of disease to improve patient outcomes. In a recent systematic review, it has been reported that isolated cases of Guillain-Barre Syndrome (GBS) have occurred secondary to COVID-19 infection. GBS is defined as a rare, but potentially fatal, immune mediated disease of peripheral nerves and nerve roots that is usually triggered by infections. The incidence of GBS can therefore increase during outbreaks of infectious diseases, as was seen during the Zika virus epidemics in 2013 in French Polynesia and...
Source: The American Journal of Emergency Medicine - Category: Emergency Medicine Authors: Source Type: research
Resumo Desde 2015 a popula ção brasileira vive com as repercussões da epidemia de Zika, levantando o debate sobre as dificuldades de diagnóstico e acesso aos cuidados para crianças com Síndrome Congênita do Zika. As regiões Nordeste e Sudeste foram as mais atingidas, desafiando-nos a caracterizar o acesso à saúde da s crianças portadoras da Síndrome Congênita do Zika nessas regiões. O objetivo deste artigo é analisar a disponibilidade e a acessibilidade dos serviços de saúde para a reabilitação...
Source: Saude e Sociedade - Category: International Medicine & Public Health Source Type: research
FINDINGSAccording to a new study by UCLA researchers and colleagues conducted in Brazil, 65% of children born to mothers infected withthe Zikavirusalsotested positive for the mosquito-borneinfection— a much higher rate than expected.The findings indicatethat even babies whohave no outward neurological or other symptoms associated with Zika can still be infected with the virus andare potentially at risk offuturedevelopmental problems.  BACKGROUNDThe study representsthe first time that the mother-to-child transmission rate of Zika has been reportedfor a group of children who were tracked over several years —...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
CONCLUSION: Women rejected abortion due to ethical conflicts based on religious beliefs and the value of motherhood. It is necessary to design social support policies for women and families affected by this problem in Colombia. Due to the international impact of the epidemic, governments should take appropriate measures to deal with future cases of Zika infections in other countries. PMID: 32660804 [PubMed - as supplied by publisher]
Source: Gaceta Sanitaria - Category: International Medicine & Public Health Tags: Gac Sanit Source Type: research
Abstract Here, we explore the dynamics of the response of the scientific community to several epidemics, including Coronavirus 2019 (COVID-19), as assessed by the numbers of clinical trials, publications, and level of research funding over time. All six prior epidemics studied [bird flu, severe acute respiratory syndrome (SARS), swine flu, Middle East Respiratory Syndrome (MERS), Ebola, and Zika] were characterized by an initial spike of research response that flattened shortly thereafter. Unfortunately, no antiviral medications have been discovered to date as treatments for any of these diseases. By contrast, the...
Source: Drug Discovery Today - Category: Drugs & Pharmacology Authors: Tags: Drug Discov Today Source Type: research
From 2013 to 2015, sanitary authorities reported an increased incidence of Guillain-Barré syndrome (GBS) associated with Zika virus (ZIKV) in French Polynesia, Caribbean, and Brazil.1–3 After the end of ZIKV epidemics, GBS cases where still above the usual limits in countries where the arrival of chikungunya virus (CHIKV) was also a concern.3
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, All Infections, Viral infections, Post-infectious, Guillain-Barre syndrome Clinical/Scientific Notes Source Type: research
Discussions with the U.S. Food and Drug Administration (FDA) have taken place to define the required data set for filing US licensure. About Janssen’s Ebola Vaccine Regimen The Janssen preventive Ebola vaccine regimen, Ad26.ZEBOV and MVA-BN-Filo, utilizes a non-replicating viral vector strategy in which viruses – in this case adenovirus serotype 26 (Ad26) and Modified Vaccinia Virus Ankara (MVA) – are genetically modified so that they cannot replicate in human cells. In addition, these vectors carry the genetic code of several Ebola virus proteins in order to trigger an immune response.Janssen’s vac...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
ilde;es CLB Abstract Zika virus (ZIKV) epidemic and its association with severe neurological syndromes have raised worldwide concern. Despite the great clinical relevance of this infection, no vaccine or specific treatment is available and the search for antiviral compounds against ZIKV is extremely necessary. Several natural compounds, such as silymarin, exhibit antioxidant, hepatoprotective, and antiviral properties; however, the antiviral potential of this compound remains partially investigated. Therefore, the objective of this study was to evaluate in vitro the antiviral activity of silymarin against ZIKV inf...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research
by Kris V. Parag, Christl A. Donnelly The effective reproduction number,Rt, is a key time-varying prognostic for the growth rate of any infectious disease epidemic. Significant changes inRt can forewarn about new transmissions within a population or predict the efficacy of interventions. InferringRt reliably and in real-time from observed time-series of infected (demographic) data is an important problem in population dynamics. The renewal or branching process model is a popular solution that has been applied to Ebola and Zika virus disease outbreaks, among others, and is currently being used to investigate the ongoing CO...
Source: PLoS Computational Biology - Category: Biology Authors: Source Type: research
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