Frequent expression of conventional endothelial markers in pleural mesothelioma: usefulness of claudin-5 as well as combined traditional markers to distinguish mesothelioma from angiosarcoma

Pleural malignant mesothelioma is a representative mesothelial malignant tumor, and the causal relevance of past exposure to asbestos is well recognized. The current World Health Organization (WHO) classification includes three subtypes of mesothelioma: epithelioid, sarcomatoid, and biphasic.1 Epithelioid mesothelioma lesions generally express mesothelial markers such as calretinin, Wilms ’ tumor-1 (WT-1), and podoplanin (D2-40), so antibody panels are useful for diagnosing the condition. On the other hand, sarcomatoid mesothelioma lesions are often negative for some of these antibodies, and therefore the diagnosis must sometimes be made on the basis of keratin expression only.

Source: Lung Cancer - July 28, 2020 Category: Cancer & Oncology Authors: Yasuhiro Nakashima, Kentaro Inamura, Hironori Ninomiya, Sakae Okumura, Mingyon Mun, Susumu Kirimura, Masashi Kobayashi, Kenichi Okubo, Yuichi Ishikawa Source Type: research