Hyperhomocysteinemia: an instigating factor for periodontal disease.

This study aims to investigate a HHcy mouse model (cystathionine β-synthase deficient; CBS+/-) for studying the potential pathophysiological changes, if any, in the periodontium (gingiva, periodontal ligament, cement and alveolar bone). We compared periodontium, side-by-side; CBS+/- model with that of wild-type; WT (C57BL/6J) mice. Histology and histomorphometry of mandibular bone along with gene expression analyses were carried out. Also, pro-angiogenic proteins and metalloproteinases were studied. To our knowledge, this research shows, for the first time, a direct connection between periodontal disease during CBS deficiency thereby suggesting the existence of disease drivers during hyperhomocysteinemic condition. Our findings offer opportunities to develop diagnostics/therapeutics for the people who suffer from chronic metabolic disorders like HHcy. PMID: 32721223 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research