Pharmacokinetics and Pharmacodynamics of Subcutaneous Sarilumab and Intravenous Tocilizumab Following Single-Dose Administration in Patients With Active Rheumatoid Arthritis on Stable Methotrexate.

In conclusion, despite differences in PK, the onset of the decrease in CRP (efficacy) and ANC (safety) after a single dose were similar for subcutaneous sarilumab and intravenous tocilizumab. PD effects and safety were consistent with previous studies. PMID: 32726514 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32726514?dopt=Abstract

Source: The Journal of Clinical Pharmacology - July 28, 2020 Category: Drugs & Pharmacology Authors: Paccaly AJ, Kovalenko P, Parrino J, Boyapati A, Xu C, van Hoogstraten H, Ishii T, Davis JD, DiCioccio AT Tags: J Clin Pharmacol Source Type: research