Lipid carriers mediated targeted delivery of nutraceuticals: Challenges, role of blood brain barrier and promises of nanotechnology based ap-proaches in neuronal disorders.

Lipid carriers mediated targeted delivery of nutraceuticals: Challenges, role of blood brain barrier and promises of nanotechnology based ap-proaches in neuronal disorders. Curr Drug Metab. 2020 Jul 28;: Authors: Aslam M, Javed MN, Deeb HH, Nicola MK, Sabir AM, Hasnain MS, Alam MS, Waziri A Abstract Despite all significant research in discovering new therapeuticals, there has been an alarming rate of reported neurological disorders. However, the delivery of these neurotherapeuticals within the brain region is still a significant chal-lenge in the clinical management of neuronal disorders. Here, characteristic of the blood-brain barrier and blood-cerebrospinal fluid barrier serves the purpose of a physiological barrier to restrict the passage of systemic bioavailable neu-rotherapeuticals inside the brain, owing to low permeability and drug localization issues. The major advantage of such lipid-based delivery systems is that these are effective non-invasive techniques-based approaches that enable targeting of neuro-therapeuticals into the central nervous system. In the case of poorly water-soluble drugs, these lipid-based carriers not onlyfavor to increase bioavailability by enabling better solubility characteristics in the gastrointestinal tract but such encapsulat-ed neurotherapeuticals loads within the systems; may also favor stability. While owing to their small size and lipid-based composition, they offer enhanced permeability acr...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research