Inflammatory Diseases and Vitamin E —What Do We Know and Where Do We Go?

Inflammatory diseases are a significant global burden, with the multiprotein complex NLRP3 being conducted as a key player. Vitamin E is considered the most effective nutritional antioxidant, with additional anti ‐inflammatory properties. Thus, vitamin E is a promising dietary therapeutic agent. This review gives an overview on the interactions of vitamin E and inflammatory diseases and involved cellular pathways. AbstractInflammation ‐driven diseases and related comorbidities, such as the metabolic syndrome, obesity, fatty liver disease, and cardiovascular diseases cause significant global burden. There is a growing body of evidence that nutrients alter inflammatory responses and can therefore make a decisive contribution to t he treatment of these diseases. Recently, the inflammasome, a cytosolic multiprotein complex, has been identified as a key player in inflammation and the development of various inflammation‐mediated disorders, with nucleotide‐binding domain and leucine‐rich repeat pyrin domain (NLRP) 3 being t he inflammasome of interest. Here an overview about the cellular signaling pathways underlying nuclear factor “kappa‐light‐chain‐enhancer” of activated B‐cells (NF‐κB)‐ and NLRP3‐mediated inflammatory processes, and the pathogenesis of the inflammatory diseases atherosclerosis and non‐alcoholic fatty liver disease (NAFLD) is provided; next, the current state of knowledge for drug‐based and dietary‐based interventions for treatin...
Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research