Association of Aspirin and Other Nonsteroidal Anti-inflammatory Drugs With Vertebral Trabecular Bone: Data From Multiethnic Study of Atherosclerosis, a Population-Based Multicenter Cohort Study

The objective of this article was to study the association of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) with bone mineral density (BMD). Methods Spine BMD was evaluated in a subset of 2028 participants from the Multiethnic Study of Atherosclerosis cohort who were NSAID users (including aspirin) and underwent both lumbar and thoracic imaging. Multiethnic Study of Atherosclerosis is a prospective cohort study that includes 4 ethnic groups (white, Asian, African American, and Hispanic). Trabecular BMD was evaluated by quantitative computed tomography based on cardiac computed tomography images, which were obtained during coronary calcium scans. The analyses were cross sectional using baseline examination data for exposure and outcomes. Results After adjustment for potential confounders including age, sex, race, and traditional cardiovascular risk factors, a small association between trabecular BMD and baseline use of COX-2–selective NSAID was observed. COX-2–selective NSAID use was associated with 7.4 mg/cm3 (95% confidence interval [CI], 1.6–13.3; P = 0. 013) higher trabecular BMD in thoracic spine and 10.6 mg/cm3 higher at lumbar spine (95% CI, 5.1–16.1; P
Source: Journal of Computer Assisted Tomography - Category: Radiology Tags: NEURORADIOLOGY/HEAD AND NECK IMAGING Source Type: research