Alzheimer's blood test in your doctor's office closer to reality, studies say
A simple blood test to diagnose Alzheimer's disease -- on the wish list of many doctors, researchers and patients -- may be closer to becoming a reality, according to the results of studies presented virtually this week during the Alzheimer's Association International Conference 2020.
Publication date: Available online 13 August 2020Source: World Journal of Acupuncture - MoxibustionAuthor(s): Yan-jun DU, Yi-ming TAO, Qing TIAN, Peng ZENG, Wen-hui WU, Jia-huan XIAO
In conclusion, our data indicate that SZL plays its therapeutic role on AD by promoting PI3K/Akt-mTOR signalling pathway of oligodendrocytes. Thus, the present study may facilitate the therapeutic research of AD. PMID: 32774416 [PubMed]
Conclusion: These findings demonstrate the remarkable potential of these extracts as valuable source of antioxidants with interesting acetylcholinesterase inhibitory activity. PMID: 32765630 [PubMed]
Authors: Christensen MG, Damsgaard J, Fink-Jensen A Abstract BACKGROUND: Studies have consistently shown that patients with epilepsy could benefit from ketogenic diets (KDs). Recent evidence suggests that KD could be used in the treatment of central nervous system (CNS) diseases. The aim of this systematic review was to investigate the use and efficacy of KD, modified Atkins diet (MAD) and medium-chain triglyceride (MCT) diet in infants, children, adolescents, and adults with CNS diseases. METHODS: This systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-An...
Notice NOT-NS-20-089 from the NIH Guide for Grants and Contracts
Conditions: Alzheimer Disease; Musculoskeletal Pain; Chronic Pain Intervention: Behavioral: At-Home Yoga Sponsors: Palo Alto Veterans Institute for Research; National Center for Complementary and Integrative Health (NCCIH) Not yet recruiting
This study aimed to evaluate the effect of cognitive training programs on the progression of dementia in patients with early stage Alzheimer's disease dementia (ADD) at the day care center. METHODS: From January 2015 to December 2018, a total of 119 patients with early ADD were evaluated. All subjects were classified into two groups according to participate in cognitive training program in addition to usual standard clinical care. Changes in scores for minimental status examination-dementia screening (MMSE-DS) and clinical dementia rating-sum of boxes (CDR-SOB) during the 12 months were compared between two groups. Mul...
This study tested the hypothesis that differences in brain Tau amounts and in the activity of mitochondria –adenosine triphosphate (ATP)–Nuak1–Tau cascade between the neonatal and adult mice contribute to the age-dependent effects of sevoflurane on cognitive function.Methods 6- and 60-day-old mice of both sexes received anesthesia with 3% sevoflurane for 2 h daily for 3 days. Biochemical methods were used to measure amounts of Tau, phosphorylated Tau, Nuak1, ATP concentrations, and mitochondrial metabolism in the cerebral cortex and hippocampus. The Morris water maze test was used to evaluate cogn...
Publication date: Available online 5 August 2020Source: Stem Cell ResearchAuthor(s): Qiuting Dai, Wenxin Zhang, Jinghui Guo, Weihao Di, Jian Zhao, Bei Zhang, Ying Wang
CONCLUSION: Care-management and informal caregiver support for patients with Alzheimer's disease may benefit patients and result in concurrent cost savings. Increasing cognitive and social functioning through rehabilitation is indicated for more severe phases of Alzheimer's disease, and the costs appear to be compensated by savings in the cost of long-term care. PMID: 32778901 [PubMed - as supplied by publisher]