Why Transparency And Data Sharing In Clinical Trials Matters

We’re in the middle of a major flu epidemic, and the CDC has recommended treatment with an antiviral (e.g., Tamiflu or Relenza) for high-risk people. Yet there is considerable controversy over whether Tamiflu even works and, despite promises, Roche staunchly refused to release all their data for others to verify for years. The Cochrane Collaborative⁠ was finally able to review data and, in 2014, reported that Tamiflu did not reduce the number of hospitalizations, and they could not tell whether it reduced deaths. While it did reduce symptoms marginally (by less than one day), a large number of people who take it develop vomiting, headaches, or psychiatric symptoms.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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by Tyler M. Sharp, Talia M. Quandelacy, Laura E. Adams, Jomil Torres Aponte, Matthew J. Lozier, Kyle Ryff, Mitchelle Flores, Aidsa Rivera, Gilberto A. Santiago, Jorge L. Mu ñoz-Jordán, Luisa I. Alvarado, Vanessa Rivera-Amill, Myriam Garcia-Negrón, Stephen H. Waterman, Gabriela Paz-Bailey, Michael A. Johansson, Brenda Rivera-Garcia BackgroundAfter Zika virus (ZIKV) emerged in the Americas, laboratory-based surveillance for arboviral diseases in Puerto Rico was adapted to include ZIKV disease. Methods and findingsSuspected cases of arboviral disease reported to Puerto Rico Department of Health were teste...
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
The cleverest of enemies thrive on surprise attacks. Viruses—and coronaviruses in particular—know this well. Remaining hidden in animal hosts for decades, they mutate steadily, sometimes serendipitously morphing into more effective and efficient infectious agents. When a strain with just the right combination of genetic codes that spell trouble for people makes the leap from animal to human, the ambush begins. Such was the case with SARS-CoV-2, the coronavirus behind COVID-19, and the attack was mostly silent and insidious at first. Many people infected with SARS-CoV-2 remained oblivious as they served as the v...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 Magazine Source Type: news
Discussion A scoping review of facial protection for health care workers during a pandemic found that respirators such as N95 masks provide excellent protection against viruses and aerosols especially when combined with eye protection. Mask fit is an important consideration and respirators are tight fitting and therefore much less breathable and comfortable to wear for long periods of time. Surgical masks do not provide as much protection as respirators but are in general more breathable and more comfortable. Surgical masks also provide much more protection than no mask or improvised masks. Improvised masks do provide some...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
We are tantalisingly close to eradicating the disease. Things may slip backwards because of science, thugs and exponents of ignorancePolio arrives, if it announces itself at all, as a high temperature. Or a sore throat. Maybe a headache, or an upset stomach. It can go within a week or so, and be mistaken for flu. It is transmitted by poor hygiene, largely affects children under five, and many don ’t realise they’ve had it. In 5-10% of cases, however, the virus affects the nerves, paralysing the legs in particular; sometimes it reaches the lungs. For most, this is temporary. For others –30 years ago, this ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Polio Vaccines and immunisation Children Pakistan Afghanistan Hepatitis B Taliban Coronavirus outbreak Infectious diseases Health Medical research Science South and Central Asia Society Source Type: news
CONCLUSIONS: Among patients with COVID-19 hospitalised at the peak of the epidemic in China, fever, cough, and dyspnoea were the main symptoms at initial diagnosis, accompanied by lymphocytopenia and hypoxaemia. Patients with severe disease showed more severe lobe involvement and diffuse pulmonary lesion distribution. PMID: 32848097 [PubMed - as supplied by publisher]
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Abstract Interspecies transmissions of viruses between animals and humans may result in unpredictable pathogenic potential and new transmissible diseases. This mechanism has recently been exemplified by the discovery of new pathogenic viruses, such as the novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic, Middle-East respiratory syndrome-coronavirus epidemic in Saudi Arabia, and the deadly outbreak of Ebola in West Africa. The. SARS-CoV-2 causes coronavirus disease-19 (COVID-19), which is having a massive global impact in terms of economic disruption, and, above all, human health. The di...
Source: Applied Microbiology and Biotechnology - Category: Microbiology Authors: Tags: Appl Microbiol Biotechnol Source Type: research
On July 7, 2020, the Boston Red Sox pitcher Eduardo Rodriguez tested positive for the new coronavirus. He was scheduled to start Opening Day for the Sox, but the virus had other plans—damaging Rodriguez’s heart and causing a condition called myocarditis (inflammation of the heart muscle). Now the previously fit 27-year old ace left-hander must sit out the 2020 season to recover. Rodriguez is not alone in having heart damage from SARS-CoV-2, the virus that causes COVID-19. In a new study done in Germany, researchers studied the hearts of 100 patients who had recently recovered from COVID-19. The findings were al...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news
In conclusion, the public’s high level of willingness to share information, sufficient knowledge of and consensus on epidemic prevention between individuals and families, strict compliance with relevant regulations, effective preventive measures, and adequate public facilities have contributed to control of COVID-19. However, vigilance and awareness of the pandemic in some individuals, epidemic-prevention campaigns, and community-based preventive measures were insufficient. Some citizens subsequently suffered from headaches, anxiety, and mood instability. Furthermore, demographic variables (place of residence, se...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Case Report Source Type: research
ConclusionsThis report suggested that, in the early phase of COVID-19 pneumonia, routine screening could miss patients who were virus carriers. Highlighting travel history is of paramount importance for the early detection and isolation of severe acute respiratory syndrome coronavirus 2 cases.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
CONCLUSION: Susceptibility-weighted imaging, which can be used to assess the presence and severity of microhemorrhages due to diffuse axonal injury, is recommended for determining the cause of symptoms in patients with mTBI, to continue targeted treatment and prevent complications that may develop. PMID: 32589248 [PubMed - as supplied by publisher]
Source: Turkish Journal of Trauma and Emergency Surgery : TJTES - Category: Emergency Medicine Authors: Tags: Ulus Travma Acil Cerrahi Derg Source Type: research
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