Why Transparency And Data Sharing In Clinical Trials Matters

We’re in the middle of a major flu epidemic, and the CDC has recommended treatment with an antiviral (e.g., Tamiflu or Relenza) for high-risk people. Yet there is considerable controversy over whether Tamiflu even works and, despite promises, Roche staunchly refused to release all their data for others to verify for years. The Cochrane Collaborative⁠ was finally able to review data and, in 2014, reported that Tamiflu did not reduce the number of hospitalizations, and they could not tell whether it reduced deaths. While it did reduce symptoms marginally (by less than one day), a large number of people who take it develop vomiting, headaches, or psychiatric symptoms.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Source Type: news

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Cork, Ireland, March 20, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced that Health Canada has approved CABENUVA™ (cabotegravir and rilpivirine extended release injectable suspensions), the first and only once-monthly, long-acting regimen for the treatment of HIV-1 infection in adults. CABENUVA™ is indicated as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in patients who are virologically stable and suppressed (HIV-1 RNA less than 50 copies per milliliter [mL]). CABENUVA™, a co-packaged kit with t...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
ConclusionsThere has been a rapid surge in research in response to the outbreak of COVID-19. During this early period, published research primarily explored the epidemiology, causes, clinical manifestation and diagnosis, as well as prevention and control of the novel coronavirus. Although these studies are relevant to control the current public emergency, more high-quality research is needed to provide valid and reliable ways to manage this kind of public health emergency in both the short- and long-term.
Source: Infectious Diseases of Poverty - Category: Infectious Diseases Source Type: research
Abstract Tropical infectious diseases cause millions of deaths every year in developing countries with about half of the world population living at risk. Mayaro virus (MAYV) is an emerging arbovirus that causes Mayaro fever, which is characterized by fever, headache, diarrhea, arthralgia and rash. These symptoms can be clinically indistinguishable from other arboviruses, such as Dengue, Zika and Chikungunya, which makes the diagnosis and treatment of the disease more difficult. Though, Mayaro virus is a potential candidate to cause large-scale epidemics on the scale of ZIKV and CHIKV. Despite this, there is no lic...
Source: Mini Reviews in Medicinal Chemistry - Category: Chemistry Authors: Tags: Mini Rev Med Chem Source Type: research
(CNN) — As the novel coronavirus — and panic about the coronavirus — continues to spread around the world, so too are bogus claims, conspiracy theories and misinformation about the disease. There’s so much inaccurate information floating around out there that the World Health Organization is calling it an “infodemic.” In perhaps the clearest sign of the times, WHO has joined TikTok to help set the record straight. Read: Coronavirus – What You Should And Shouldn’t Do The myths exist both on the fringes of the internet and in more mainstream outlets. And while social media...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health CNN Coronavirus Source Type: news
AbstractPurpose of ReviewGiven the growing challenges in chronic pain management coupled with the ongoing consequences of the opioid epidemic, pain management practitioners are looking into more effective, innovative, and safer alternatives to treat pain. Cannabis-based medicine had been described for hundreds of years but only recently have we seen the more scientific, evidence-based approach to its use, and ongoing investigations continue to explore its potential medical benefits. While historically more attention has been paid to the psychoactive component of the cannabis plant Δ9-tetrahydrocannabinol (THC), there...
Source: Current Pain and Headache Reports - Category: Neurology Source Type: research
This study investigated the performance of various case definitions and influenza symptoms in a primary healthcare sentinel surveillance system. A retrospective study of the clinical and epidemiological characteristics of the cases reported by a primary healthcare sentinel surveillance network for eleven years in Catalonia was conducted. Crude and adjusted diagnostic odds ratios (aDORs) and 95% confidence intervals (CIs) of the case definitions and symptoms for all weeks and epidemic weeks were estimated. The most predictive case definition for laboratory-confirmed influenza was the World Health Organization (WHO) case def...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
(BANGKOK) — A Chinese visitor to Thailand has been confirmed to be infected with a new strain of coronavirus that has been linked to a pneumonia outbreak in central China, health officials said Monday. The U.N.’s World Health Organization said Thai officials have reported that a traveler from the Chinese city of Wuhan has been hospitalized in Thailand with the virus. The outbreak of the virus has been traced to Wuhan, where it affected several dozen people who had been to a major meat and seafood market. Thai Public Health Minister Anutin Charnvirakul said it appears to be the first confirmed case of the virus ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized China onetime Thailand Source Type: news
The objective of this study was to compare the clinical and laboratory findings of dengue and assess whether the serotype is a risk factor for severity.Methodology: We included patients ≤ 15 years old hospitalized with dengue at the Institute of Tropical Medicine, from Paraguay, from 2007 to 2018. Patients were classified according to the 2009 WHO dengue classification guidelines and were stratified by serotype into three groups according to the hospitalization period: the 2007 e pidemic (DENV-3), the 2012-2013 epidemic (DENV-2) and the 2016-2018 epidemic (DENV-1).Results: Of 784 children hospitalized for dengue, 50 cas...
Source: The Journal of Infection in Developing Countries - Category: Infectious Diseases Source Type: research
Advocacy groups are urging Facebook to remove advertisements that they say unfairly infer that the HIV/AIDS prevention Truvada PrEP (pre-exposure prophylaxis) is dangerous, an allegation they say could endanger the people who are most at risk of contracting the disease. More than 50 HIV/AIDs, LGBTQ and public health advocacy groups released a letter on Monday asking Facebook and Instagram to remove the ads from their platforms. The ads referred specifically to “Truvada PrEP” (the brand name for one of the medications, dtenofovir disoproxil fumarate, used as PrEP) and in some cases more generically to “PrE...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health LGBTQ onetime Source Type: news
Publication date: Available online 6 November 2019Source: Respiratory Medicine Case ReportsAuthor(s): Serao Mattia, Marianna Lilli, Angela Succu, Tiziana Trequattrini, Rossana Vigliarolo, Giuseppina Gioffrè, Rosario Rivitti, Aldo Ciani, Shakib Zyada, Silvia Candia, Maria Cristina ZappaAbstractHistoplasma capsulatum is a dimorphic fungus, non-endemic in Italy but endemic in America, Asia and tropical Africa. People who generally visit an endemic area may aspirate spores and run the risk of infection. The aerosolization of micronids or hyphal fragments is considered to cause the epidemic. In most people this fungus, w...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
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