No relation between docetaxel administration route and high ‐grade diarrhea incidence

In conclusion, our data show that the onset of severe diarrhea after oral administration of docetaxel in humans is similar after oral and intravenous administration of docetaxel and is caused by the concentration of docetaxel in the systemic blood circulation. Mouse experiments confirmed that intestinal toxicity is caused by a high systemic exposure and not by local intestinal exposure. Severe diarrhea in patients after oral docetaxel is reversible and is not related to the route of administration of docetaxel.

Source: Pharmacology Research and Perspectives - July 27, 2020 Category: Drugs & Pharmacology Authors: Jeroen J. M. A. Hendrikx, Frederik E. Stuurman, Ji ‐Ying Song, Vincent A. Weger, Jurjen S. Lagas, Hilde Rosing, Jos H. Beijnen, Alfred H. Schinkel, Jan H. M. Schellens, Serena Marchetti Tags: ORIGINAL ARTICLE Source Type: research