Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical.

Iron Fenton oxidation of 2'-deoxyguanosine in physiological bicarbonate buffer yields products consistent with the reactive oxygen species carbonate radical anion not the hydroxyl radical.
Chem Commun (Camb). 2020 Jul 27;:
Authors: Fleming AM, Burrows CJ
Abstract
Product analysis from the iron Fenton oxidation of 2'-deoxyguanosine found reactions in bicarbonate buffer yield 8-oxo-2'-deoxyguanosine and spiroiminodihyantoin consistent with CO3˙-. Reactions in phosphate buffer furnished high yields of sugar oxidation products consistent with HO˙. These observations change the view of DNA oxidation products from the iron-Fenton reaction.
PMID: 32716425 [PubMed - as supplied by publisher]

Source: Chemical Communications - July 26, 2020 Category: Chemistry Authors: Fleming AM, Burrows CJ Tags: Chem Commun (Camb) Source Type: research