A 1-to-2 demultiplexer hybrid nanocarrier for cargo delivery and activation.

A 1-to-2 demultiplexer hybrid nanocarrier for cargo delivery and activation. Chem Commun (Camb). 2020 Jul 28;: Authors: de Luis B, García-Fernández A, Llopis-Lorente A, Villalonga R, Sancenón F, Martínez-Máñez R Abstract A biocomputing strategy implemented in hybrid nanocarriers for controlled cargo delivery is described. The nanodevice consists of enzyme-functionalized Janus Au-mesoporous silica nanoparticles, which behave as an electronic demultiplexer (DEMUX). The nanocarrier is capable of reading molecular information from the environment (lactose) and selecting one of two possible outputs (galactose production or 4-methylumbellilferone release and activation) depending on the presence of an addressing input (NAD+). PMID: 32720668 [PubMed - as supplied by publisher]
Source: Chemical Communications - Category: Chemistry Authors: Tags: Chem Commun (Camb) Source Type: research