Synchronously Multiple Gastric Adenocarcinomas with Intestinal Mucin Phenotype in a Patient not Infected with Helicobacter Pylori, Showing a Gastritis-like Appearance.

This report suggested the possibility of overlooking this neoplasm. PMID: 32713922 [PubMed - as supplied by publisher]
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research

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Discussion Helicobacter pylori (H. pylori) is a microaerophilis, spiral bacterium that is a prevalent human pathogen. How this infection affects individuals is different in adults and children. Overall seroprevalence rate in children world-wide was estimated to be ~33%, but this seroprevalence rate is decreasing in the developed world for both adults and children. It is acquired in childhood and can persist through colonization throughout life if untreated. Fortunately, it often is asymptomatic and generally does not cause serious disease in children. Some serotyping data shows that within families children acquire it more...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Endoscopy DOI: 10.1055/a-0859-1883Patients with chronic atrophic gastritis or intestinal metaplasia (IM) are at risk for gastric adenocarcinoma. This underscores the importance of diagnosis and risk stratification for these patients. High definition endoscopy with chromoendoscopy (CE) is better than high definition white-light endoscopy alone for this purpose. Virtual CE can guide biopsies for staging atrophic and metaplastic changes and can target neoplastic lesions. Biopsies should be taken from at least two topographic sites (antrum and corpus) and labelled in two separate vials. For patients with mild to moderate atrop...
Source: Endoscopy - Category: Gastroenterology Authors: Tags: Guideline Source Type: research
Authors: White JR, Sami SS, Reddiar D, Mannath J, Ortiz-Fernández-Sordo J, Beg S, Scott R, Thiagarajan P, Ahmad S, Parra-Blanco A, Kasi M, Telakis E, Sultan AA, Davis J, Figgins A, Kaye P, Robinson K, Atherton JC, Ragunath K Abstract BACKGROUND: Patient outcomes in gastric adenocarcinoma are poor due to late diagnosis. Detecting and treating at the premalignant stage has the potential to improve this. Helicobacter pylori is also a strong risk factor for this disease. AIMS: Primary aims were to assess the diagnostic accuracy of magnified narrow band imaging (NBI-Z) endoscopy and serology in detecting norm...
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
Conclusion: ME-NBI with VSCS can identify the DL in most patients (88.2%) with differentiated-type early gastric cancer afterHp eradication.Digestion 2018;98:175 –184
Source: Digestion - Category: Gastroenterology Source Type: research
In this study, the progression of precancerous lesions after H pylori treatment was evaluated. Patients with incomplete or complete intestinal metaplasia and/or gastric atrophy at the index endoscopy, were examined for the extension/histological worsening of precancerous lesions at the endoscopy surveillance for gastric cancer. Progression of lesions was evaluated according to H pylori status, age, and sex. Cox proportional hazard regression model and Kaplan–Meier curves were used to evaluate the strength of predictors for lesions progression. Among 105 patients (61 women) H pylori negative patients showed a milder...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Gastric cancer is a major cause of cancer-related mortality in the world and results in over 10,000 deaths per year in the United States (US). Risk factors such as family history, smoking, high salt intake, and Helicobacter pylori (HP) infection have been well established. Atrophic gastritis, gastric intestinal metaplasia (GIM), and dysplasia are known precursor lesions to gastric adenocarcinoma (ADCA). The rate of progression to ADCA, however, is not known, and no surveillance guidelines exist in the US.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstract Source Type: research
A Western study using serological tests for gastric mucosal atrophy and H. pylori status suggested two distinct etiologies of esophagogastric junction (EGJ) cancer i.e. H. pylori associated atrophic gastritis and non-atrophic gastric mucosa resembling esophageal adenocarcinoma (Gut 2007;56:918 –925). In this multicenter collaborative study, we investigated whether the same aspect (two distinct etiologies) exists in Japanese patients with superficial EGJ cancer.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Monday – ASGE poster Source Type: research
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Source: Digestive Endoscopy - Category: Gastroenterology Authors: Tags: Letters, techniques and images Source Type: research
Endosc Int OpenDOI: 10.1055/s-0042-105869 Background and study aims: We previously reported that narrow-band imaging with magnifying endoscopy (NBI-ME) revealed a unique “gastritis-like” appearance in approximately 40 % of early gastric cancers after Helicobacter pylori eradication. Because rates of gastric cancer are increasing in patients with non-persistent infection of H. pylori, we aimed to clarify contribution factors to obscure tumors after therapeutic or spontaneous eradication. Patients and methods: NBI-ME findings were examined retrospectively in 194 differentiated-type adenocarcinoma...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Abstract We aimed to study MLH1 and MGMT methylation status in Helicobacter pylori-associated chronic gastritis in Egyptian patients with and without gastric cancer. 39 patients were included in our study. They were divided into 2 groups; patients without (group I) and with gastric adenocarcinoma (group II). Patients were subjected to clinical examination, abdominal ultrasound and upper endoscopy for gastric biopsy. Biopsies were subjected to urease test, histological examination, and DNA purification. H. pylori, Braf, Kras, MLH1 and MGMT methylation were assessed by quantitative PCR. DNA sequencing was performed...
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
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