Sequencing identifies a distinct signature of circulating microRNAs in early radiographic knee osteoarthritis

MicroRNAs act locally and systemically to impact osteoarthritis pathophysiology, but comprehensive profiling of the circulating miRNome in early versus late stages of osteoarthritis has yet to be conducted. Sequencing has emerged as the preferred method for microRNA profiling since it offers high sensitivity and specificity. Our objective is to sequence the miRNome in plasma from 91 patients with early [Kellgren-Lawrence grade 0 or 1 (n=41)] or late [Kellgren-Lawrence grade 3 or 4 (n=50)] symptomatic radiographic knee osteoarthritis to identify unique microRNA signatures in each disease state.

Source: Osteoarthritis and Cartilage - July 28, 2020 Category: Rheumatology Authors: Shabana Amanda Ali, Rajiv Gandhi, Pratibha Potla, Sareh Keshavarzi, Osvaldo Espin-Garcia, Konstantin Shestopaloff, Chiara Pastrello, Dylan Bethune-Waddell, Starlee Lively, Anthony V. Perruccio, Y. Raja Rampersaud, Christian Veillette, Jason S. Rockel, Igo Source Type: research