“Retinoid-related orphan receptor RORγt in CD4+T cell–mediated intestinal homeostasis and inflammation.”

ROR γt, a retinoid orphan nuclear receptor and the master transcription factor of the Th17 subset of CD4+T helper cells, is one of the most promising targets to treat a host of autoimmune diseases. This includes the inflammatory bowel diseases (IBD)—Crohn’s disease (CD) and ulcerative colitis (UC)— caused by untoward reactivity of the immune system to the components of the intestinal microbiome. The mammalian intestinal tract is a highly complex and compartmentalized organ with specialized functions, and is a privileged site for the generation of both peripherally induced regulatory CD4+ T cel ls (Treg) and effector T helper 17 (Th17) cells.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research