EMA Panel Backs Filgotinib (Jyseleca) for Rheumatoid Arthritis EMA Panel Backs Filgotinib (Jyseleca) for Rheumatoid Arthritis

Filgotinib is an oral Janus kinase 1 inhibitor for adult patients with moderate to severe active RA who have responded inadequtely to or are intolerant of other therapies.International Approvals
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Rheumatology News Alert Source Type: news

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We present our experiences in conducting multicenter investigations to provide insight into this demanding and rewarding frontier of research. PMID: 32732659 [PubMed - in process]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Conclusions Individuals with homozygosity of rs231775 CTLA4 variant represented AA disease risk and increased severity than their counterparts. Abbreviations AA: Alopecia areata; CTLA4: Cytotoxic T-lymphocyte Associated Protein 4; SNP: Single nucleotide polymorphism; LADA: Latent autoimmune diabetes in adults; SLE: Systemic lupus erythematosus; SCU: Suez Canal University; SALT: Severity of Alopecia Tool; DNA: Deoxyribonucleic acid; RT-PCR: Real-time polymerase chain reaction, HWE: Hardy-Weinberg equation; RA: rheumatoid arthritis. PMID: 32731768 [PubMed - as supplied by publisher]
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
AbstractActivated neutrophils release neutrophil extracellular traps (NETs) in response to a variety of stimuli. NETosis is driven by protein-arginine deiminase type 4, with the release of intracellular granule components that function by capturing and destroying microbes, including viral, fungal, bacterial, and protozoal pathogens. The positive effects of pathogen control are countered by pro-inflammatory effects as demonstrated in a variety of diseases. Components of NETS are non-specific, and other than controlling microbes, they cause injury to surrounding tissue by themselves or by increasing the pro-inflammatory resp...
Source: Clinical Reviews in Allergy and Immunology - Category: Allergy & Immunology Source Type: research
AbstractPurpose of the ReviewA growing number of studies have suggested that disease outcomes and response to therapy may be different in patients with rheumatoid arthritis (RA) who are obese. The goal of this review is to examine the most recent literature, with a focus on the impact of obesity on the assessment of disease activity and treatment outcomes in RA.Recent FindingsObesity is common in patients with RA and can have a substantial impact on patient symptoms and outcomes. Obesity is associated with higher rates of chronic pain and opiate use, elevated inflammatory markers, and less reliable physical exam findings, ...
Source: Current Rheumatology Reports - Category: Rheumatology Source Type: research
AbstractTetramerized single-chain variable fragment (ScFv) of anti-cyclic citrullinated peptide (TeAb-CCP) is a constructed tetramerized ScFv of anti-cyclic citrullinated peptide (CCP) antibodies with p53 tetrameric domain, aim to investigate its effect on fibroblast-like synoviocytes (FLSs) proliferation, migration, invasion, and production of inflammatory mediators in thein vitro co-culture system of peripheral mononuclear cells (PBMCs) and FLSs. TeAb-CCP was constructed by modifying a monovalent ScFv antibody to CCP with p53 tetrameric domain to improve its affinity. FLSs were isolated and cultured from rheumatoid arthr...
Source: Inflammation - Category: Allergy & Immunology Source Type: research
ConclusionseRA individuals have high levels of leptin and vaspin. However, the presence of periodontitis and related-periodontal disease markers showed an effect only in leptin levels in eRA individuals.Clinical relevanceEmphasizing in personalized medicine, monitoring serum leptin levels and periodontitis markers can improve the early diagnosis of RA.
Source: Clinical Oral Investigations - Category: Dentistry Source Type: research
A 63-year-old woman who was a nonsmoker was referred to our department with a 2-year history of recurrent seronegative rheumatoid arthritis. Each episode had resolved within 1 to 2 weeks  after prednisone therapy (20 mg/day). Physical examination revealed painful and inflammatory joint effusion of the knees and ankles and digital clubbing of all fingers and toes (Figure 1). Further elicitation of her history revealed similar symptoms every 4 months since age 2 years. The remainder of physical examination findings were unremarkable.
Source: Mayo Clinic Proceedings - Category: Internal Medicine Authors: Tags: Medical image Source Type: research
RHEUMATOID arthritis does not always affect a person's joints. Health experts advise if you have this problem with your breathing or in your lungs, you should see a GP immediately - it may be an early sign of the condition.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
CONCLUSIONS: Although the report mainly includes the most severe cases, its temporal and spatial trend supports the validity of the national surveillance system. More complete data are being acquired in order to both test the hypothesis that RMD patients may have a different outcome from that of the general population and determine the safety of immunomodulatory treatments. PMID: 32723435 [PubMed - in process]
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research
Authors: Manfredi A, Luppi F, Cassone G, Vacchi C, Salvarani C, Sebastiani M Abstract INTRODUCTION: Main clinical manifestations of SARS-CoV-2 infection are characterized by fever, cough, dyspnoea and interstitial pneumonia frequently evolving in an acute respiratory distress syndrome (ARDS). AREAS COVERED: Features of coronavirus disease 2019 (COVID-19) pneumonia presents some common points with interstitial lung disease (ILD) both idiopathic and related to rheumatoid arthritis (RA), typically characterized by a chronic progression over some years and possibly complicated by acute exacerbation. The study of so...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
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