Determinants of neurological outcome in neonates with congenital heart disease following heart surgery.

CONCLUSION: For HLHS and d-TGA patients, duration of mechanical ventilation and DHCA are associated with adverse neurologic outcome. Neonatal brain MRI commonly demonstrates acquired brain injuries, but the clinical impact of these abnormalities are not often seen before 2 years of age. IMPACT: Acquired brain injury is common in high-risk neonates with CHD but poor neurological outcome was not predicted by severity of injury or lesion subtype. Longer stay in ICU is associated with postoperative brain injuries on MRI.Total duration of ventilation > 12 days is predictive of adverse neurological outcome scores.DHCA > 40 min is associated with adverse neurological outcome scores.Neurological outcome before 2 years of age is more affected by the clinical course than by cardiac diagnosis. PMID: 32711400 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research