Motor repertoire is age-inadequate in infants with cystic fibrosis.

CONCLUSIONS: Infants with genetically anticipated severe CF phenotype tended to have lower MOS. MOS may be used in addition to genetic testing to predict disease severity in infants with CF. Infants with CF, absent/sporadic FMs, and lower MOS could be considered for planning specific age-adequate early intervention programs. IMPACT: Motor repertoire was age-inadequate in infants with cystic fibrosis (CF).50% of infants with CF had abnormal or absent/sporadic fidgety movements (FMs).Motor optimality score (MOS) was positively associated with vitamin A level and negatively correlated with hospitalization duration in infants with CF.MOS tended to decrease as genetically anticipated disease severity increased; thus, MOS might enable us to predict disease severity in CF. The relationship between motor repertoire and phenotype and genotype is unclear and warrants further study.CF infants with absent/sporadic FMs, and lower MOS could be considered for planning early intervention. PMID: 32717740 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research