The rationale for repurposing funny current inhibition for management of ventricular arrhythmia

Management of ventricular arrhythmia in structural heart disease is complicated by the toxicity of the limited antiarrhythmic options available. In others, pro-arrhythmia, deleterious hemodynamic, and noncardiac effects prevent practical use. This necessitates new thinking in therapeutic agents for ventricular arrhythmia in structural heart disease. Ivabradine, a funny current (If) inhibitor, has proven safety in heart failure, angina, and inappropriate sinus tachycardia. Though it is commonly known that funny channels are primarily expressed in the sinoatrial node, atrioventricular node, and conducting system of the ventricle, ivabradine is known to exert effects on metabolism, ion homeostasis and membrane electrophysiology of remodeled ventricular myocardium.
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research