A cocrystal structure of dengue capsid protein in complex of inhibitor [Microbiology]

Dengue virus (DENV) was designated as a top 10 public health threat by the World Health Organization in 2019. No clinically approved anti-DENV drug is currently available. Here we report the high-resolution cocrystal structure (1.5 Å) of the DENV-2 capsid protein in complex with an inhibitor that potently suppresses DENV-2...

Source: Proceedings of the National Academy of Sciences - July 27, 2020 Category: Science Authors: Hongjie Xia, Xuping Xie, Jing Zou, Christian G. Noble, William K. Russell, Luis Marcelo F. Holthauzen, Kyung H. Choi, Mark A. White, Pei-Yong Shi Tags: Biological Sciences Source Type: research