Icariin Modulates eNOS Activity Via Effect On Post ‐translational Protein‐protein Interactions To Improve Erectile Function of Spontaneously Hypertensive Rats

ConclusionUp ‐regulating the expression of HSP90 and calmodulin and inhibiting caveolin‐1 in SHR corpus cavernosum, promoting the interaction between eNOS and HSP90, inhibiting the interaction between eNOS and caveolin‐1, increasing p‐eNOS/eNOS, may be the mechanism of icariin that improves SHR erectile function.
Source: Andrology - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research