Cancers, Vol. 12, Pages 2090: Mapping and Quantification of Non-Coding RNA Originating from the rDNA in Human Glioma Cells

In this study, we demonstrate that the region ~2 kb upstream of the rDNA promoter is transcriptionally active in one type of the most malignant human brain tumors, and we compare its expression rate to that of healthy human tissues and cell cultures. Sense and antisense non-coding RNA transcripts were detected and mapped, but their secondary structure and functions remain to be elucidated. We propose that the transcripts may relate to a new class of so-called promoter-associated RNAs (pRNAs), or have some other regulatory functions. We also hope that the expression of these non-coding RNAs can be used as a marker in glioma diagnostics and prognosis.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research