Ingenuity pathway analysis of differentially expressed genes involved in signaling pathways and molecular networks in RhoE gene ‑edited cardiomyocytes.

In conclusion, the present study successfully edited the RhoE gene in H9C2 cells using CRISPR/Cas9 technology and subsequently analyzed the enriched DEGs along with their associated canonical signaling pathways, diseases and functions classification, upstream regulatory molecules, regulatory effects and interaction networks. The results of the present study should facilitate the discovery of the global biological and functional properties of RhoE and provide new insights into role of RhoE in human diseases, especially those in the cardiovascular system.
PMID: 32705255 [PubMed - in process]

Source: International Journal of Molecular Medicine - July 28, 2020 Category: Molecular Biology Authors: Shao Z, Wang K, Zhang S, Yuan J, Liao X, Wu C, Zou Y, Ha Y, Shen Z, Guo J, Jie W Tags: Int J Mol Med Source Type: research