Dexmedetomidine Ameliorates Renal Ischemia Reperfusion-Mediated Activation of the NLRP3 Inflammasome in Alveolar Macrophages.

In conclusion, our study demonstrated that the protective action of DEX in AMs is induced through amelioration of HMGB1-NLRP3 inflammasome-AMPK signaling. Our results suggest that the anesthetic reagent DEX exerts beneficial effects to ameliorate rI/R-induced ALI. PMID: 32707303 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32707303?dopt=Abstract

Source: Gene - July 20, 2020 Category: Genetics & Stem Cells Authors: Chen Y, Huang Y, Xiong B, Luo H, Song X Tags: Gene Source Type: research

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