Ocular and Systemic Pharmacokinetics of Brimonidine and Brinzolamide After Topical Administration in Rabbits: Comparison Between Fixed-combination and Single-drug Formulations.

CONCLUSIONS: FCBB achieved drug distribution in the aqueous humor and systemic exposure that were comparable to those for the single-drug formulations. The viscosity of FCBB may increase BMD distribution in the retina/choroid. The administration interval affects ocular drug absorption with the concomitant administration of 0.1% BMD and 1% BZM, which can be overcome by using the fixed-combination of both drugs.
PMID: 32706598 [PubMed - as supplied by publisher]

Source: Current Eye Research - July 23, 2020 Category: Opthalmology Authors: Suzuki G, Kunikane E, Shigemi W, Shinno K, Kozai S, Kurata M, Kawamura A Tags: Curr Eye Res Source Type: research