A Micro-Engineered Airway Lung-Chip Models Key Features of Viral-Induced Exacerbation of Asthma.

In conclusion, our micro-engineered Airway Lung-Chip provides a novel human-relevant platform for exploring the complex mechanisms underlying viral-induced asthma exacerbation. Our data suggest that IL-13 may impair the hosts' ability to mount an appropriate and coordinated immune response to rhinovirus infection. We also show that the Airway Lung-Chip can be used to assess the efficacy of modulators of the immune response.
PMID: 32706623 [PubMed - as supplied by publisher]

Source: Am J Respir Cell Mol... - July 23, 2020 Category: Respiratory Medicine Authors: Nawroth JC, Lucchesi C, Cheng D, Shukla A, Ngyuen J, Shroff T, Varone A, Karalis K, Lee HH, Alves S, Hamilton GA, Salmon M, Villenave R Tags: Am J Respir Cell Mol Biol Source Type: research