Plasma Cell Myeloma Presenting With Amyloid-Laden Crystal-Negative Histiocytosis.

CONCLUSIONS: We describe a case of crystal-negative histiocytosis associated with PCM. CSH is a rare disorder associated with paraprotein-producing conditions in which immunoglobulins aggregate as intracellular crystals in the lysosomes of organ-specific phagocytic macrophages. Light chain tropism in PCM can also lead to the development of amyloid deposition in organs and, in rare cases, is associated with light chain aggregation as intracellular crystals in macrophages.
PMID: 32705137 [PubMed - as supplied by publisher]

Source: American Journal of Clinical Pathology - July 23, 2020 Category: Pathology Authors: Braunstein MJ, Petrova-Drus K, Rosenbaum CA, Jayabalan DS, Rossi AC, Salvatore S, Rech K, Pearse RN, Hassane DC, Postley J, Jhanwar YS, Geyer JT, Niesvizky R Tags: Am J Clin Pathol Source Type: research