Genetic and clinical predictors of arthralgia during letrozole or anastrozole therapy in breast cancer patients

ConclusionsOur results suggested that BMI and AI drug (letrozole versus anastrozole) were clinical predictors of arthralgia, while genetic variants rs4775936, rs9322336, rs2234693, and rs9340799 were genetic predictors of AI-induced arthralgia. Significantly, rs4775936 was also a predictor of discontinuation of therapy.

http://link.springer.com/10.1007/s10549-020-05777-1

Source: Breast Cancer Research and Treatment - July 26, 2020 Category: Cancer & Oncology Source Type: research