OxLDL-mediated immunologic memory in endothelial cells

Trained innate immunity describes the metabolic reprogramming and long-term proinflammatory activation of innate immune cells in response to different pathogen or damage associated molecular patterns, such as oxidized low-density lipoprotein (oxLDL). Here, we have investigated whether the regulatory networks of trained innate immunity also control endothelial cell activation following oxLDL treatment. Human aortic endothelial cells (HAECs) were primed with oxLDL for 24  h. After a resting time of 4 days, cells were restimulated with the TLR2-agonist PAM3cys4.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research