Erythropoietin is a major regulator of thrombopoiesis in thrombopoietin- dependent and –independent context

The process of differentiation of hematopoietic stem cells into functional blood cells involves a continuum of organized, stable and hierarchical intermediate stages ranging from multipotent to unipotent progenitor cells. In the canonical hematopoiesis, megakaryocyte and erythroid lineages are closely related and share a common bipotent megakaryocytic and erythroid progenitor (MEP) (1, 2). Recently, several studies have demonstrated the existence of hematopoietic stem cells (HSC) with megakaryocyte-biased differentiation potential at the apex of the hematopoietic hierarchy in normal and stress hematopoiesis suggesting that commitment to the megakaryocyte lineage could also occur at an earlier stage, bypassing erythroid versus megakaryocyte lineage bifurcation (3-8).

Source: Experimental Hematology - July 24, 2020 Category: Hematology Authors: Salima Hacein-Bey-Abina, Machadiya Estienne, St éphanie Bessoles, Hamid Echchakir, Magali Pederzoli-Ribeil, Andrada Chiron, Lydia Aldaz-Carroll, Valentin Leducq, Yanyan Zhang, Michèle Souyri, Fawzia Louache, Amine M. Abina Source Type: research