Bone marrow adipocytes enhance osteolytic bone destruction by activating 1q21.3(S100A7/8/9-IL6R)-TLR4 pathway in lung cancer

ConclusionsOur study suggested that bone marrow adipocyte may communicate with lung cancer cells via 1q21.3 (S100A8/A9-IL6R)-TLR4 pathway to promote osteolytic bone destruction. 1q21.3 (S100A8/A9-IL6R) is a potential target for the treatment of lung cancer bone metastasis.

http://link.springer.com/10.1007/s00432-020-03277-9

Source: Journal of Cancer Research and Clinical Oncology - July 26, 2020 Category: Cancer & Oncology Source Type: research