Cytotoxic Hydroperoxycochliodinol Derivative from Endophytic Chaetomium sp. Isolated from Salvia officinalis

The endophytic fungusChaetomium sp. was separated from the medicinal plantSalvia officinalis growing in Egypt and cultivated on solid rice medium. Chemical investigation of the EtOAc extract yielded a new hydroperoxycochliodinol derivative (1) in addition to several known compounds, which included cochliodinol (2), isocochliodinol (3), chaetomin (4), and two simple indole derivatives (5,6). The structure of the new compound was determined by comprehensive NMR studies including DEPT, COSY, HMQC, HMBC, and HR-MS. All compounds were tested for their cytotoxic activity against L5178Y cells. Compounds1,2, and4 showed cytotoxic activity with EC50 values between 3.5 –5.0 μg/mL, whereas compounds3,5, and6 were inactive.
Source: Chemistry of Natural Compounds - Category: Chemistry Source Type: research