Pharmacokinetics and pharmacodynamics of a novel analgesic with a deterrent to human opioid abuse (methadone-fluconazole-naltrexone) after oral administration in dogs.

CONCLUSIONS AND CLINICAL RELEVANCE: Opioid effects were detected after oral administration of methadone-fluconazole or methadone-fluconazole-naltrexone. Further studies assessing additional opioid effects, including antinociception, are needed. PMID: 32700999 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32700999?dopt=Abstract

Source: American Journal of Veterinary Research - July 25, 2020 Category: Veterinary Research Authors: KuKanich B, KuKanich K, Rankin DC, Locuson CW, Joo H Tags: Am J Vet Res Source Type: research

More News: Fluconazole | Methadone | Study | Substance Abuse | Veterinary Research