Genetic Deletion of Galectin-3 Alters the Temporal Evolution of Macrophage Infiltration and Healing Affecting the Cardiac Remodeling and Function after Myocardial Infarction in Mice
We studied the role of galectin-3 (Gal-3) in the expression of alternative activation markers (M2) on macrophage, cytokines, and fibrosis through the temporal evolution of healing, ventricular remodeling, and function after myocardial infarction (MI). C57BL/6J and Gal-3 knockout mice (Lgals3-/-) were subjected to permanent coronary ligation or sham. We studied i) mortality, ii) macrophage infiltration and expression of markers of alternative activation, iii) cytokine, iv) matrix metalloproteinase-2 activity, v) fibrosis, and vi) cardiac function and remodeling.
Source: American Journal of Pathology - Category: Pathology Authors: Pablo Cassaglia, Federico Penas, Celeste Betazza, Florencia Fontana Estevez, Ver ónica Miksztowicz, Nadia Martínez Naya, María Clara Llamosas, Sofía Noli Truant, Luciana Wilensky, Verónica Volberg, Ágata C. Cevey, Vanessa Touceda, Eliana Cicale, Gab Tags: Regular article Source Type: research