Impact of image reconstruction method on dose distributions derived from90Y PET images: phantom and liver radioembolization patient studies.

Conclusions: In this90Y radioembolization PET/CT study, the β parameter in regularized iterative (Q.Clear) reconstruction was investigated for image quality, accurate quantification and dose distributions based on phantom experiments and then applied to patient studies. Our results indicate that more accurate dose distribution can be achieved from smoother PET images, reconstructed with larger β values than those yielding the best activity quantification, but noisy images. Most importantly, these results suggest that, quantitative measures, which are commonly used in clinics, such as SUVmaxor SUVpeak(equivalent of Dmax), should not be employed for90Y PET images, since their values would highly depend on the image reconstruction. PMID: 32702673 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32702673?dopt=Abstract

Source: Physics in Medicine and Biology - July 22, 2020 Category: Physics Authors: Hou X, Ma H, Esquinas PL, Uribe CF, Tolhurst S, Bénard F, Liu D, Rahmim A, Celler A Tags: Phys Med Biol Source Type: research