Isotyping paranodal antibodies in inflammatory neuropathies: One step closer to precision care

The discovery of autoantibodies against paranodal proteins such as neurofascin-155 (NF155), contactin-1 (CNTN1), or contactin-associated protein-1 (CASPR1) in inflammatory neuropathies has led to the description of subsets of patients with specific phenotypic features.1 These antibodies mostly belong to the immunoglobulin G (IgG)4 subclass, but IgG1, IgG2, or IgG3 autoantibodies have also been described.2–4 Different autoantibody isotypes are associated with different effector mechanisms causing nerve damage5,6; testing them may have implications to inform therapeutic choices or to predict prognosis.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, All Neuromuscular Disease, Peripheral neuropathy, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy Editorial Source Type: research