Antiparanodal antibodies and IgG subclasses in acute autoimmune neuropathy

Conclusion Our data (1) confirm and extend previous observations that antiparanodal IgG2/3 but not IgG4 antibodies can occur in acute-onset neuropathies manifesting as monophasic GBS, (2) suggest association of IgG3 to a favorable response to IVIg, and (3) lend support to the hypothesis that in some patients, an IgG subclass switch from IgG3 to IgG4 may be the correlate of a secondary progressive or relapsing course following a GBS-like onset.

http://nn.neurology.org/cgi/content/short/7/5/e817?rss=1

Source: Neurology Neuroimmunology and Neuroinflammation - July 23, 2020 Category: Neurology Authors: Appeltshauser, L., Brunder, A.-M., Heinius, A., Körtvelyessy, P., Wandinger, K.-P., Junker, R., Villmann, C., Sommer, C., Leypoldt, F., Doppler, K. Tags: Autoimmune diseases, All Neuromuscular Disease, Peripheral neuropathy, Guillain-Barre syndrome, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research