Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression

ConclusionMTX triggers ICD by activating eIF2 α via PERK/GCN2 upregulation in prostate cancer cells. MTX-induced PERK expression upregulation depends on the p53 pathway, while that of GCN2 requires further investigation.

Source: Cellular Oncology - July 23, 2020 Category: Cancer & Oncology Source Type: research