Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology .
Neurobiology and the Hierarchical Taxonomy of Psychopathology: progress toward ontogenetically informed and clinically useful nosology
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Dialogues Clin Neurosci. 2020 Mar;22(1):51-63
Authors: Perkins ER, Joyner KJ, Patrick CJ, Bartholow BD, Latzman RD, DeYoung CG, Kotov R, Reininghaus U, Cooper SE, Afzali MH, Docherty AR, Dretsch MN, Eaton NR, Goghari VM, Haltigan JD, Krueger RF, Martin EA, Michelini G, Ruocco AC, Tackett JL, Venables NC, Waldman ID, Zald DH
Abstract
The Hierarchical Taxonomy of Psychopathology (HiTOP) is an empirical structural model of psychological symptoms formulated to improve the reliability and validity of clinical assessment. Neurobiology can inform assessments of early risk and intervention strategies, and the HiTOP model has greater potential to interface with neurobiological measures than traditional categorical diagnoses given its enhanced reliability. However, one complication is that observed biological correlates of clinical symptoms can reflect various factors, ranging from dispositional risk to consequences of psychopathology. In this paper, we argue that the HiTOP model provides an optimized framework for conducting research on the biological correlates of psychopathology from an ontogenetic perspective that distinguishes among indicators of liability, current symptoms, and consequences of illness. Through this approach, neurobiological research can contribute more effectively to identifying indiv...
Source: Dialogues in Clinical Neuroscience - Category: Neuroscience Tags: Dialogues Clin Neurosci Source Type: research