Histamine 2/3 receptor agonists alleviate perioperative neurocognitive disorders by inhibiting microglia activation through the PI3K/AKT/FoxO1 pathway in aged rats

Microglia, the principal sentinel immune cells of the central nervous system (CNS), play an extensively vital role in neuroinflammation and perioperative neurocognitive disorders (PND). Histamine, a potent med...

Source: Journal of Neuroinflammation - July 22, 2020 Category: Neurology Authors: Yi-Nan Chen, Huan-Huan Sha, Yi-Wei Wang, Qin Zhou, Piplu Bhuiyan, Na-Na Li, Yan-Ning Qian and Hong-Quan Dong Tags: Research Source Type: research