A Novel Long-Term Graves ’ Disease Animal Model Confirmed by Functional Thyrotropin Receptor Antibodies

Conclusions: TBAb/TSAb were highly prevalent in Ad-TSHR-immunized mice, thus confirming the successful establishment of a novel, long-term murine model for GD. All TBAb- and TSAb-positive Ad-TSHR-immunized mice were TBII-positive. Thus, the binding immunoassay did not differentiate between TSHR-Ab functionality.Eur Thyroid J
Source: European Thyroid Journal - Category: Endocrinology Source Type: research