Different effect of amiodarone and dofetilide on the dispersion of repolarization between well coupled ventricular and Purkinje fibers.

In conclusion, amiodarone decreased the dispersion between PF and VM, while dofetilide increased it. The measured difference in APD between cardiac regions may be the affected by electrotonic coupling, thus studying PF and VM separately may lead to an over or underestimation of dispersion.
PMID: 32692935 [PubMed - as supplied by publisher]

Source: Canadian Journal of Physiology and Pharmacology - July 20, 2020 Category: Drugs & Pharmacology Authors: Árpádffy-Lovas T, Husti Z, Baczkó I, Varró A, Virág L Tags: Can J Physiol Pharmacol Source Type: research