The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-seventh Adult Heart Transplantation Report — 2020; Focus on Deceased Donor Characteristics

Heart transplantation continues to be limited by a paucity of donor organs despite innovations in organ procurement and organ preservation, greater willingness to accept marginal hearts (such as those from older donors with medical comorbidities such as diabetes and hypertension, left ventricular hypertrophy, and left ventricular dysfunction) and use of hearts from donors who died of drug overdose, donors with hepatitis C viremia and donors after circulatory death.(1, 2) These developments have expanded the donor pool and have changed perceptions and practices with respect to consideration of heart transplant donors.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Original Clinical Science Source Type: research

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Authors: Bergland OU, Søraas CL, Larstorp ACK, Halvorsen LV, Hjørnholm U, Hoffman P, Høieggen A, Fadl Elmula FEM Abstract PURPOSE: The blood pressure (BP) lowering effect of renal sympathetic denervation (RDN) in treatment-resistant hypertension shows variation amongst the existing randomised studies. The long-term efficacy and safety of RDN require further investigation. For the first time, we report BP changes and safety up to 7 years after RDN, compared to drug adjustment in the randomised Oslo RDN study. MATERIALS AND METHODS: Patients with treatment-resistant hypertension, defined...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Zhang W, Xu JZ, Lu XH, Li H, Wang D, Wang JG Abstract PURPOSE: We hypothesise that dietary sodium intake interacts with serum uric acid to influence blood pressure (BP) in children and adolescents. In the present study, we investigated ambulatory BP in relation to hyperuricaemia, dietary sodium intake and their interaction in children and adolescents with hypertension. MATERIALS AND METHODS:  A total of 616 study participants were 10-24 years old and had primary hypertension diagnosed after admission in a specialised inpatient ward. Ambulatory BP monitoring was performed during hospitalisat...
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
CONCLUSION: The proposed PHARMAC criteria will give access to these important drugs to those people with T2DM who will likely benefit the most. PMID: 33032305 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Authors: Siamashvili M, Davis S Abstract INTRODUCTION: Bromocriptine mesylate quick release (QR) is a dopamine D2 receptor agonist and is the only oral, primarily centrally acting drug that can be used for the treatment of adults with type 2 diabetes. AREAS COVERED: The authors describe current recommendations on the use of bromocriptine mesylate QR. Major efficacy and safety parameters of the late phase trials, including The Cycloset Safety Trial, have been identified and presented. EXPERT OPINION: Efficacy of bromocriptine mesylate QR monotherapy appears to be low but is compensated by favorable safety pr...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research
WASHINGTON (AP) — Fatal drug overdoses are increasing organ donations, and researchers reported Monday that people who receive those transplants generally fare as well as patients given organs from more traditional donors. The findings could encourage more use of organs from overdose victims. Researchers from Johns Hopkins University found those transplants have jumped nearly 24-fold since 2000. That was before overdoses were making headlines or most transplant centers considered accepting such organs. In 2016, there were 3,533 transplants using overdose-related donated organs, up from just 149 such transplants in 20...
Source: JEMS Patient Care - Category: Emergency Medicine Authors: Tags: Patient Care News Source Type: news
Conclusion: The opioid crisis in the United States has substantially altered the kidney donor pool. Strategies to increase utilization of all potentially viable kidneys for transplant are needed, particularly in this era of new, highly effective, direct-acting antiviral therapy for HCV infection.Am J Nephrol 2018;47:84 –93
Source: American Journal of Nephrology - Category: Neurology Source Type: research
CONCLUSION: The opioid crisis in the United States has substantially altered the kidney donor pool. Strategies to increase utilization of all potentially viable kidneys for transplant are needed, particularly in this era of new, highly effective, direct-acting antiviral therapy for HCV infection. PMID: 29439266 [PubMed - as supplied by publisher]
Source: American Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: Am J Nephrol Source Type: research
Imagine a chronic medical condition in which the treatment itself has serious side effects. Examples of this are plentiful in medicine. For example, in diabetes, giving too much insulin can cause hypoglycemia (low blood sugar), a dangerous and potentially life-threatening condition. That doesn’t happen very often, but imagine that it was a common complication of treating diabetes because doctors couldn’t really tell how powerful a given dose of insulin actually was. And suppose that doctors and patient safety experts advocated for places where patients with diabetes could be carefully monitored when taking thei...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Addiction Behavioral Health Brain and cognitive health Mental Health Pain Management Source Type: blogs
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