Cortisol profiles and clinical severity in MECP2 duplication syndrome

ConclusionsFuture mechanistic studies will have to determine whether the declining CAR in MDS is attributable to problems with “flip-flop switching” of regional brain activation (involving the suprachiasmatic nucleus and the hippocampus, and the HPA axis) that is responsible for the switch from reduced to increased adrenal sensitivity. Taken together, results suggest the possibility that cortisol profiles could potentia lly be a biomarker of clinical severity and utilized for the purposes of patient stratification for future clinical trials in MDS.
Source: Journal of Neurodevelopmental Disorders - Category: Neurology Source Type: research