Metabolomic analysis in ophthalmology.

Metabolomic analysis in ophthalmology. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2020 Jul 17;: Authors: Nazifova-Tasinova N, Radeva M, Galunska B, Grupcheva C Abstract Modern science takes into account phenotype complexity and establishes approaches to track changes on every possible level. Many "omics" studies have been developed over the last decade. Metabolomic analysis enables dynamic measurement of the metabolic response of a living system to a variety of stimuli or genetic modifications. Important targets of metabolomics is biomarker development and translation to the clinic for personalized diagnosis and a greater understanding of disease pathogenesis. The current review highlights the major aspects of metabolomic analysis and its applications for the identification of relevant predictive, diagnostic and prognostic biomarkers for some ocular diseases including dry eye, keratoconus, retinal diseases, macular degeneration, and glaucoma. A Medline search of recent studies was made on metabolomic analysis for identification of biomarkers in ocular diseases, using keywords such as "biomarkers, "metabolomics", "ocular diseases", "macular degeneration", "dry eye", "keratoconus", "retinal diseases", inflammatory eye diseases", "glaucoma", and "diabetic retinopathy". To date, possible biomarker candidates for dry eye disease are lipid metabolites and androgens, for keratoconus cytokeratins, urea, citrate cycle, and oxidative...
Source: Biomedical Papers of the Medical Faculty of the Univ Palacky Olomouc Czech Repub - Category: Biomedical Science Tags: Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub Source Type: research