Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma.

Into Thin Air: Hypoxia Drives Metabolic and Epigenomic Deregulation of Lethal Pediatric Ependymoma. Dev Cell. 2020 Jul 20;54(2):134-136 Authors: Englinger B, Hack OA, Filbin MG Abstract Posterior fossa type A (PFA) ependymoma is a lethal pediatric brain tumor proposed to be driven solely by epigenetic deregulation. Michealraj et al. (2020) demonstrate that hypoxia reprograms PFA metabolism and, subsequently, the epigenome toward H3K27 hypomethylation, mirroring transcriptional and metabolic signatures of gliogenic progenitors involved in embryonal hindbrain development. PMID: 32693052 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32693052?dopt=Abstract

Source: Developmental Cell - July 19, 2020 Category: Cytology Authors: Englinger B, Hack OA, Filbin MG Tags: Dev Cell Source Type: research