Can vasohibin-1, an endothelium-derived angiogenesis inhibitor, be a marker of endothelial dysfunction in hemodialysis patients?

CONCLUSIONS: Hemodialysis patients have low serum vasohibin-1 levels but serum levels of vasohibin-1 did not show any significant relationship with FMD, PWV, and CIMT in HD patients. Since vasohibin-1 acts via paracrine pathways, serum levels may be insufficient to explain the relationship between vasohibin and ED. Local vasohibin-1 activity on tissue level may be more important instead of circulating levels.
PMID: 32686227 [PubMed - as supplied by publisher]

Source: Seminars in Dialysis - July 18, 2020 Category: Urology & Nephrology Authors: Altunoren O, Kerkutluoglu M, Sarısık FN, Akkus G, Seyithanoglu M, Doganer A, Tutuncu Sezal D, Cagrı Aykan A, Eren N, Erken E, Gungor O Tags: Semin Dial Source Type: research