CDK7 inhibitor THZ1 enhances antiPD-1 therapy efficacy via the p38 α/MYC/PD-L1 signaling in non-small cell lung cancer

The cyclin-dependent kinase 7 (CDK7) subunit of TFIIH regulates RNA polymerase-II-based transcription and promotes tumor progression. However, the mechanisms involved in CDK7-mediated immune evasion are unclea...

Source: Journal of Hematology and Oncology - July 20, 2020 Category: Hematology Authors: Jian Wang, Ruiguang Zhang, Zhenyu Lin, Sheng Zhang, Yaobing Chen, Jing Tang, Jiaxin Hong, Xiaoshu Zhou, Yan Zong, Yingzhuo Xu, Rui Meng, Shuangbing Xu, Li Liu, Tao Zhang, Kunyu Yang, Xiaorong Dong & hellip; Tags: Research Source Type: research