ESTIMATED PREVALENCE OF THE DUFFY NULL PHENOTYPE Fy (a −b−) AMONG BLACK BLOOD-DONORS IN SOUTHWESTERN COLOMBIA

Hemolytic reactions are adverse complications associated with red blood cell transfusion. These reactions are associated with clinically important erythrocyte antigens, such as those of Duffy blood Meny (2010). Individuals with the Duffy null phenotype Fy (a  − b−) are more likely to develop an alloimmunization reaction, resulting in an incompatibility with all available red blood cell units, thus increasing the risk of complications from their underlying disease Höher et al. (2018). Hence, it is important to determine the prevalence of the Fy (a − b−) phenotype in blood donors in our population and to create a database to ensure safe transfusion in patients with this phenotype.

Source: Transfusion and Apheresis Science - July 21, 2020 Category: Hematology Authors: Marcela Quintero-Santacruz, Liliana Fl órez Elvira, Ana Fernanda Mejía Hurtado, Carmenza Macia Mejía Source Type: research