Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner.

Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner. Can J Physiol Pharmacol. 2020 Jul 20;: Authors: Maeda T, Horiuchi T, Makino N Abstract The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere of circulating leukocytes in association with age (-41.9bp/year, p=0.045) in contrast to controls (-18.3kb/year, p=0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (-16.4bp/year, p=0.372) in contrast to controls (-55.9bp/year, p=0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background life-style associated diseases promoting biological aging. PMID: 32687724 [PubMed - as supplied by publisher]
Source: Canadian Journal of Physiology and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Can J Physiol Pharmacol Source Type: research